反应详情

To a solution of 4-methyl-5-phenylimidazole (250 mg, 1.58 mmol) in 5 mL DMF at rt, were added TEA (242 μL, 1.74 mmol) and TrCl (485 mg, 1.74 mmol). The mixture was stirred at rt for 20 h, then was diluted with EtOAc, washed with H2O (2×) and brine, dried (Na2SO4) and concentrated. The crude product was purified by flash chromatography (0 to 50% EtOAc/hexanes gradient) to afford 504 mg of Intermediate 20.1 as a white solid.

1. washwashed with H2O (2×) and brine
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated
4. customThe crude product was purified by flash chromatography (0 to 50% EtOAc/hexanes gradient)