反应详情

A mixture of 5,6-dimethyl-1H-benzo[d]imidazole (500 mg, 3.42 mmol), trityl chloride (1.05 g, 3.76 mmol) and TEA (524 μL, 3.76 mmol) in 5 mL DMF was stirreds at rt for 3 h. The mixture was diluted with EtOAc, washed with H2O and brine, dried (Na2SO4) and concentrated. The crude residue was purified by flash chromatography (0 to 100% EtOAc/hexanes gradient) to afford 1.31 g of Intermediate 415.1.

1. customat rt
2. customfor 3 h
3. washwashed with H2O and brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated
6. customThe crude residue was purified by flash chromatography (0 to 100% EtOAc/hexanes gradient)