反应详情

温度

50 °C

A mixture of 2,4-dichloropyrimidine (2.97 g, 20 mmol), 3-amino-5-methyl-1H-pyrazole (2.14 g, 22 mmol), and N,N-diisopropylethylamine (2.82 g, 22 mmol) in dry THF (75 ml) was stirred at 50° C. for 18 hours. The solvent was removed by evaporation, and the residue partitioned between DCM (75 ml) and water (50 ml). The resulting precipitate was collected by filtration washed with water and then ether, and dried under vacuum at 50° C. to give the title compound (1.08 g, 26%) as a colourless crystalline solid.

1. customThe solvent was removed by evaporation
2. customthe residue partitioned between DCM (75 ml) and water (50 ml)
3. filtrationThe resulting precipitate was collected by filtration
4. washwashed with water
5. dry with materialether, and dried under vacuum at 50° C.