2-Bromopropane → HCID 68815501, compound

HRID 2105940Notes

Reaction equation

HRID 2105940 reaction equation
[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1([OH:18])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(=O)([O-])[O-].[K+].[K+].Br[CH:26]([CH3:28])[CH3:27]>C(#N)C>[F:1][C:2]1[C:7]([C:8]([F:10])([F:11])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1([OH:18])[CH2:17][CH2:16][N:15]([CH:26]([CH3:28])[CH3:27])[CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 63582-BromopropaneHCID 11430Potassium CarbonateHCID 68813278HCID 68813278, compound

Product 1

HCID 68815501HCID 68815501, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 2: 4-[2-fluoro-3-(trifluoromethyl)phenyl]piperidin-4-ol (0.02 g, 0.076 mmol), acetonitrile (2 ml), potassium carbonate (0.02 g, 0.14 mmol), 2-bromopropane (0.008 ml, 0.082 mmol). MS m/z (relative intensity, 70 eV) 305 (M+, 5), 290 (79), 191 (30), 163 (18), 56 (bp).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-7522129691f641a1a9774215cc082fe2
Source dataset
uspto-grants-2009_08
Patent number
US07579474B2

Reaction notes

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