Ethyl bromoacetate → HCID 57810562, compound

HRID 2106474Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([OH:17])=[C:13]([CH:16]=1)[CH:14]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21].C([O-])([O-])=O.[K+].[K+].C1CCN2C(=NCCC2)CC1>>[CH2:23]([O:22][C:20]([C:19]1[O:17][C:12]2[CH:11]=[CH:10][C:9]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:16][C:13]=2[CH:14]=1)=[O:21])[CH3:24]

Participants

Reactant 4

HCID 7748Ethyl bromoacetate

HCID 11430Potassium Carbonate

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

HCID 8783625-(Benzyloxy)-2-hydroxybenzaldehyde

Product 1

HCID 57810562HCID 57810562, compoundYield 84%

Procedure

5-Benzyloxy-2-hydroxy-benzaldehyde ((21.5 g, 94.2 mmol) and ethyl bromoacetate (17.3 g, 103.6 mmol) and K2CO3 (19.5 g, 141.3 mmol) and DBU (14.3 g, 94.2 mmol) are reacted analogous to Example 18-A to give the title compound (23.5 g, 84%).

Sources & evidence

ORD record: ord-02df3d77817646a0a9ed2620b43b5297
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579488B2

Reaction notes

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