Ammonium Hydroxide → HCID 15016284, compound

HRID 2106602Notes

Reaction equation

HRID 2106602 reaction equation
[C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:8]=1)[CH3:5])(O)=[O:2].C(N1C=CN=C1)([N:24]1C=CN=C1)=O.[OH-].[NH4+]>>[NH2:24][C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:8]=1)[CH3:5])=[O:2]

Participants

4

Reactant 3

HCID 14923Ammonium HydroxideHCID 682631,1'-CarbonyldiimidazoleHCID 15016262HCID 15016262, compound

Product 1

HCID 15016284HCID 15016284, compoundYield 56.2%

Procedure

The process was carried out as was Example 45, starting with 5 g of the compound of Example 24, 4 g of carbonyldiimidazole and 1.2 g of ammonium hydroxide. The yield was 2.8 g of the desired product, m.p. 147°-149°.

Sources & evidence

ORD record
ord-c8a1e1f5d35c4796b9f3626e994fa199
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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