Methylamine → HCID 15016286, compound

HRID 2106604Notes

Reaction equation

HRID 2106604 reaction equation
[C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[N:8]=1)[CH3:5])([OH:3])=O.[C:19](N1C=CN=C1)([N:21]1C=CN=C1)=O.CN>>[Cl:18][C:14]1[CH:13]=[C:12]([N:9]2[CH:10]=[N:11][C:7]([O:6][CH:4]([C:1]([NH:21][CH3:19])=[O:3])[CH3:5])=[N:8]2)[CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 15016263HCID 15016263, compound

Product 1

HCID 15016286HCID 15016286, compoundYield 73.1%

Procedure

The process was carried out as was Example 45, starting with 3 g of the compound of Example 25, 2.7 g of carbonyldiimidazole, and 3 ml of 40% aqueous methylamine. The product was recrystallized from toluene to obtain 2.3 g of the desired product, m.p. 120°-122°.

Workup

  1. customThe product was recrystallized from toluene

Sources & evidence

ORD record
ord-6a834459e3bd4792a6966ae6a339b383
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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