Ammonium Hydroxide → HCID 15016295, compound

HRID 2106614Notes

Reaction equation

HRID 2106614 reaction equation
[C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)[N:8]=1)[CH3:5])(O)=[O:2].C(N1C=CN=C1)([N:21]1C=CN=C1)=O.[OH-].[NH4+]>CN(C)C=O>[NH2:21][C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)[N:8]=1)[CH3:5])=[O:2]

Participants

5

Reactant 3

HCID 14923Ammonium HydroxideHCID 682631,1'-CarbonyldiimidazoleHCID 15016294HCID 15016294, compound

Product 1

HCID 15016295HCID 15016295, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Two g of the product of Example 58 was dissolved in 10 ml of dimethylformamide and 1.9 g of carbonyldiimidazole was added. The mixture was stirred at room temperature for 20 minutes, and 0.6 g of 35% ammonium hydroxide was added. The mixture was then stirred for 20 hours at room temperature and was poured over ice-water. The product was collected by filtration and dried to obtain 1.4 g of the desired product, m.p. 156°-158°.

Workup

  1. stirringThe mixture was then stirred for 20 hours at room temperature
  2. filtrationThe product was collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-407bb2d0019e4f189ac3d7bf4a860274
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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