HCID 54303576, compound → HCID 54183520, compound

HRID 2106957Notes

Reaction equation

HRID 2106957 reaction equation
[CH2:1]([O:3][C:4](=[S:19])[C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[C:7]([N+:14]([O-])=O)[C:6]=1[CH2:17][CH3:18])[CH3:2]>O1CCCC1.[Ni].C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[S:19])[C:5]1[CH:10]=[C:9]([NH2:11])[CH:8]=[C:7]([NH2:14])[C:6]=1[CH2:17][CH3:18])[CH3:2]

Participants

5

Reactant 1

HCID 54303576HCID 54303576, compound

Product 1

HCID 54183520HCID 54183520, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

25.9 g (0.0862 mol) of 3,5-dinitro-2-ethylthiobenzoic acid ethyl ester are dissolved in 260 ml of tetrahydrofuran and hydrogenated at 30°-35° C. in the presence of 10 g of Raney nickel. The catalyst is then isolated by filtration, and the residue is taken up in ethyl acetate, dried over magnesium sulfate, filtered and concentrated.

Workup

  1. customThe catalyst is then isolated by filtration
  2. dry with materialdried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-cc648c61fc16444d8bb7d87dc7b53176
Source dataset
uspto-grants-1990_06
Patent number
US04931581

Reaction notes

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