Hydrochloric Acid → HCID 15053527, compound

HRID 2107238Notes

Reaction equation

HRID 2107238 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:11])[C:8]([O-:10])=[O:9])[N:6]=1.[K+].[CH2:13](O)[CH:14]([CH3:16])[CH3:15].Cl.C(=O)([O-])[O-].[K+].[K+]>O.O1CCOCC1>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:11])[C:8]([O:10][CH2:13][CH:14]([CH3:16])[CH3:15])=[O:9])[N:6]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6560IsobutanolHCID 11430Potassium CarbonateHCID 23682514HCID 23682514, compound

Product 1

HCID 15053527HCID 15053527, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

A mixture comprising 10 g of potassium 2-aminothiazol-4-ylglyoxylate, 15 g of isobutyl alcohol and 50 ml of a 4N dioxane solution of hydrogen chloride was stirred at room temperature for 2 days. The reaction mixture was poured into water and neutralized with potassium carbonate, followed by extraction with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and the ethyl acetate was evaporated off under reduced pressure, giving the desired compound as a pale yellow powder.

Workup

  1. extractionfollowed by extraction with ethyl acetate
  2. dry with materialThe extract was dried over anhydrous magnesium sulfate
  3. customthe ethyl acetate was evaporated off under reduced pressure

Sources & evidence

ORD record
ord-ddfb3caee31d41778d3d3bfb63dc1d7d
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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