Morpholine → Ethyl 2-(morpholin-4-yl)-1,3-thiazole-4-carboxylate

HRID 2107289Notes

Reaction equation

HRID 2107289 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]1[S:9][CH:10]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:12]=1.C(N(CC)CC)C>CN(C)C=O>[O:4]1[CH2:5][CH2:6][N:1]([C:8]2[S:9][CH:10]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:12]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 8471TriethylamineHCID 13106141Ethyl 2-chlorothiazole-4-carboxylate

Product 1

HCID 15053544Ethyl 2-(morpholin-4-yl)-1,3-thiazole-4-carboxylate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The reaction described in Preparation 26 was repeated, but using 1.4 g of morpholine, 3 g of ethyl 2-chlorothiazole-4-carboxylate. 3 g of triethylamine and 12 ml of dimethylformamide, giving the title compound as colorless needles.

Workup

  1. customThe reaction described in Preparation 26

Sources & evidence

ORD record
ord-b46b1738171d4f99b3f6b71f8b2ba682
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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