反应详情

A mixture of 2-bromopyridine (2.0 g), N-[6-[(2-propynyl)oxy]hexyl]benzenemethanamine (3.2 g), BTPC (0.07 g), cuprous iodide (0.007 g), and diethylamine (20 ml) was stirred under nitrogen for 18 h, treated with aqueous sodium bicarbonate (1M, 50 ml), and extracted with diethyl ether (2×100 ml). The dried extract was evaporated and the residue was purified by FCC eluting with diethyl ether to give the title compound as a yellow oil (3.0 g), t.l.c. (diethyl ether) Rf 0.05.

1. extractionextracted with diethyl ether (2×100 ml)
2. extractionThe dried extract
3. customwas evaporated
4. customthe residue was purified by FCC
5. washeluting with diethyl ether