Piperidine → HCID 57633160, compound

HRID 2108762Notes

Reaction equation

HRID 2108762 reaction equation
Cl[CH2:2][CH2:3][CH2:4][S:5]([NH:8][C:9]1[CH:10]=[C:11]([CH2:15][C:16]([NH:18][C:19]2[S:20][CH:21]=[C:22]([C:24]3[C:32]4[C:27](=[N:28][CH:29]=[CH:30][CH:31]=4)[NH:26][CH:25]=3)[N:23]=2)=[O:17])[CH:12]=[CH:13][CH:14]=1)(=[O:7])=[O:6].[NH:33]1[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1>CN(C=O)C>[N:33]1([CH2:2][CH2:3][CH2:4][S:5]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][C:16]([NH:18][C:19]3[S:20][CH:21]=[C:22]([C:24]4[C:32]5[C:27](=[N:28][CH:29]=[CH:30][CH:31]=5)[NH:26][CH:25]=4)[N:23]=3)=[O:17])[CH:12]=[CH:13][CH:14]=2)(=[O:7])=[O:6])[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 57633187HCID 57633187, compound

Product 1

HCID 57633160HCID 57633160, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

The crude 2-[3-(3-chloro-propane-1-sulfonylamino)-phenyl]-N-[4-(1H-pyrrolo [2,3-b]pyridin-3-yl)-thiazol-2-yl]-acetamide was treated with neat piperidine and heated to 100° C. overnight. The reaction mixture was diluted with DMF and purified by preparative HPLC to give the desired compound.

Workup

  1. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-919ec5783eda4c0fa9a9b33034708f5c
Source dataset
uspto-grants-2009_04
Patent number
US07514448B2

Reaction notes

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