反应详情

温度

70 °C

3.00 g 6-amino-nicotinic acid are dissolved in 30 ml of dimethylformamide and 4.05 g of N,N-carbonyldiimidazole are added. The mixture is briefly heated to 70° C. and then stirred for a further hour at ambient temperature. After this time 4.85 ml of N-methylpiperazine are added and the mixture is stirred for 12 hours at ambient temperature. The solvent is eliminated and the residue is purified through a silica gel column with methylene chloride/ethanol/ammonia 7:1:0.1 as eluant.

1. stirringthe mixture is stirred for 12 hours at ambient temperature
2. customthe residue is purified through a silica gel column with methylene chloride/ethanol/ammonia 7:1:0.1 as eluant