Ethyl Acetate → HCID 86610507, compound

HRID 2110039Notes

Reaction equation

HRID 2110039 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH2:15])[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:16][N:17]=[C:18]=[S:19].CCOC(C)=O>C1COCC1>[C:4]([O:3][C:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:18]([NH:17][CH3:16])=[S:19])[CH2:10][CH2:9]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 11167Methyl isothiocyanateHCID 7368171-Boc-4-(aminomethyl)piperidine

Product 1

HCID 86610507HCID 86610507, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

After dissolving 1-Boc-4-aminomethylpiperidine (642 mg, 3 mmol) in THF (8 ml), methyl isothiocyanate (241 mg, 3.3 mmol) was added and the mixture was stirred at room temperature overnight. Upon completion of the reaction, purification was performed by silica gel column chromatography (Hex/AcOEt=1/4) to obtain 4-({[(methylamino)thioxomethyl]amino}methyl)piperidine carboxylic acid tert-butyl ester. The compound was identified by LC-MS.

Workup

  1. additionwas added
  2. customUpon completion of the reaction, purification

Sources & evidence

ORD record
ord-4aae7c5d3cda4e91bdf0cc3ef1797c40
Source dataset
uspto-grants-2009_04
Patent number
US07517875B2

Reaction notes

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