反应详情

温度

90 °C

A mixture of methyl 3-{4-[(3-bromobenzyl)oxy]phenyl}propanoate (0.3 g, 0.86 mmol), 1,2,3,4-tetrahydroquinoline (0.17 mL, 1.29 mmol), tris(dibenzylideneacetone)dipalladium(0) (31 mg, 34 μmol), rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (32 mg, 52 μmol), cesium carbonate (0.39 g, 1.2 mmol) and toluene (6.0 mL) was stirred under a nitrogen atmosphere at 90° C. for 16 hr. After cooling, the reaction mixture washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give an oil. Then, a mixture of the obtained oil, 1N aqueous sodium hydroxide solution (1.7 mL), methanol (2.0 mL) and tetrahydrofuran (4.0 mL) was stirred at room temperature for 2 hr. The reaction mixture was concentrated, and the residue as partitioned between ethyl acetate and 1N hydrochloric acid. The organic layer was dried and concentrated under reduced pressure. The residue was purified by preparative HPLC (gradient cycle A), and the object fractions were collected and concentrated. Water was added to the residue, and the mixture was adjusted to pH 7 with saturated aqueous sodium hydrogencarbonate and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title compound (60 mg, yield 18%) as a beige powder. MS (APCI−): 386 (M−H).

1. temperatureAfter cooling
2. washthe reaction mixture washed with water and saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customto give an oil
6. stirringwas stirred at room temperature for 2 hr
7. concentrationThe reaction mixture was concentrated
8. customthe residue as partitioned between ethyl acetate and 1N hydrochloric acid
9. customThe organic layer was dried
10. concentrationconcentrated under reduced pressure
11. customThe residue was purified by preparative HPLC (gradient cycle A), and the object fractions
12. customwere collected
13. concentrationconcentrated
14. additionWater was added to the residue
15. extractionextracted with ethyl acetate
16. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
17. concentrationconcentrated under reduced pressure