Potassium Iodide → HCID 11223065, compound

HRID 2111816Notes

Reaction equation

HRID 2111816 reaction equation
[CH2:1]([C:3]1[N:12]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22]Cl)=[CH:15][CH:14]=2)[C:11](=[O:24])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1)[CH3:2].[NH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CN(C)C=O>[CH2:1]([C:3]1[N:12]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][N:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)=[CH:15][CH:14]=2)[C:11](=[O:24])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1)[CH3:2]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 8082PiperidineHCID 11430Potassium CarbonateHCID 23151266HCID 23151266, compound

Product 1

HCID 11223065HCID 11223065, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

2-ethyl-3-[4-(3-chloropropoxy)phenyl]-4(3H)-quinazolinone (19 g, 55.6 mmol), piperidine (23.7 g, 278 mmol), potassium carbonate (11.5 g, 83.4 mmol) and potassium iodide (13.8 g, 83.4 mmol) were mixed in dimethylformamide (400 mL) and stirred at 80° C. for 24 hours.

Sources & evidence

ORD record
ord-4acc56a69cc9477596f66d2a79f5c635
Source dataset
uspto-grants-2009_04
Patent number
US07521455B2

Reaction notes

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