Triethylamine → HCID 57640052, compound

HRID 2112106Notes

Reaction equation

HRID 2112106 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:24]=[CH:23][CH:22]=[C:21]4[C:17]=3[C:18](=[O:29])[N:19]([CH2:26][CH2:27][F:28])[CH:20]4[CH3:25])[C:12]([C:30]([F:33])([F:32])[F:31])=[CH:11][N:10]=2)=[C:4]([O:34][CH3:35])[CH:3]=1.C(N(CC)CC)C.[C:43](Cl)(=[O:46])[CH:44]=[CH2:45]>C1COCC1.C(OCC)(=O)C>[C:43]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:24]=[CH:23][CH:22]=[C:21]4[C:17]=3[C:18](=[O:29])[N:19]([CH2:26][CH2:27][F:28])[CH:20]4[CH3:25])[C:12]([C:30]([F:32])([F:33])[F:31])=[CH:11][N:10]=2)=[C:4]([O:34][CH3:35])[CH:3]=1)(=[O:46])[CH:44]=[CH2:45]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 86606185HCID 86606185, compound

Product 1

HCID 57640052HCID 57640052, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

311 mg (0.634 mmol) 2-(4-amino-2-methoxy-phenylamino)-4-(2-(2-fluoro-ethyl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-ylamino)-5-trifluoromethyl-pyrimidine are dissolved in 10 ml THF and combined with 115 μl (0.824 mmol) triethylamine and 62 μl (0.761 mmol) acrylic chloride. This mixture is stirred for 1 h at ambient temperature. Then it is diluted with ethyl acetate and extracted three times with water. The organic phase is dried with magnesium sulphate and the solvent is eliminated in vacuo.

Workup

  1. extractionextracted three times with water
  2. dry with materialThe organic phase is dried with magnesium sulphate

Sources & evidence

ORD record
ord-2df532c6eac648f584107c5af2bb1b09
Source dataset
uspto-grants-2009_04
Patent number
US07521457B2

Reaction notes

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