反应详情

Potassium carbonate (0.152 g) and (2-bromomethyl)benzonitrile (0.216 g) were added to a solution of 3-benzyl-4-chloro1,3-dihydroimidazo[4.5-c]pyridin-2-one (0.259 g) in N,N-dimethylformamide (5 mL). This was stirred at room temperature for 16 hours. Ethyl acetate (60 mL) and water (30 mL) were added, and the organic layer was washed twice with 30 mL of water and once with 30 mL of saturated aqueous sodium chloride solution. This was then dried over anhydrous magnesium sulfate. The organic layer was filtered and concentrated under reduced pressure, and the residue was then purified by silica gel chromatography. The ethyl acetate:hexane 3:2 fraction gave the title compound (0.364 g).

1. washthe organic layer was washed twice with 30 mL of water and once with 30 mL of saturated aqueous sodium chloride solution
2. dry with materialThis was then dried over anhydrous magnesium sulfate
3. filtrationThe organic layer was filtered
4. concentrationconcentrated under reduced pressure
5. customthe residue was then purified by silica gel chromatography