Diethylamine → HCID 68639007, compound

HRID 2115190Notes

Reaction equation

HRID 2115190 reaction equation
C1C2C(COC(=O)[N:17]([CH2:24][CH2:25][CH2:26][CH2:27][C:28](=[O:59])[NH:29][C:30]3[CH:35]=[CH:34][C:33]([N:36]4[C:39](=[O:40])[CH:38]([CH2:41][CH2:42][CH:43]([OH:50])[C:44]5[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=5)[CH:37]4[C:51]4[CH:56]=[CH:55][C:54]([O:57][CH3:58])=[CH:53][CH:52]=4)=[CH:32][CH:31]=3)C3C=CC=CC=3)C3C(=CC=CC=3)C=2C=CC=1.C(NCC)C>CN(C)C=O>[OH:50][CH:43]([C:44]1[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=1)[CH2:42][CH2:41][CH:38]1[C:39](=[O:40])[N:36]([C:33]2[CH:32]=[CH:31][C:30]([NH:29][C:28](=[O:59])[CH2:27][CH2:26][CH2:25][CH2:24][NH2:17])=[CH:35][CH:34]=2)[CH:37]1[C:51]1[CH:56]=[CH:55][C:54]([O:57][CH3:58])=[CH:53][CH:52]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 86593153HCID 86593153, compound

Product 1

HCID 68639007HCID 68639007, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

570 mg (0.78 mmol) of product 8 and 0.8 ml of diethylamin are solved in 5 ml of DMF (dimethylformamid). It is evaporated after 1 h at room temperature. The residue is purified by flash chromatography (methylenchloride/methanol/conc. ammoniac 30:10:3) 220 mg (56%) of product 9 is obtained in form of an amorphic solid compound: C30H35N3O4 (501.63) MS (ESI+) 502.3 (M+H+).

Workup

  1. customIt is evaporated after 1 h at room temperature
  2. customThe residue is purified by flash chromatography (methylenchloride/methanol/conc. ammoniac 30:10:3) 220 mg (56%) of product 9
  3. customis obtained in form of an amorphic solid compound

Sources & evidence

ORD record
ord-8db41afd9d174245a944c87151b1cc59
Source dataset
uspto-grants-2008_10
Patent number
US07435727B2

Reaction notes

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