反应详情

A mixture of the product from step (i) (1.04 g), potassium carbonate (1.025 g) and ethyl iodide (0.637 g) in N,N-dimethylformamide (15 ml ) was stirred vigorously at room temperature for 2 h. The mixture was partitioned between ethyl acetate and water, the organics washed with water, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 2:1 ethyl acetate in isohexane. Yield 0.63 g

1. customThe mixture was partitioned between ethyl acetate and water
2. washthe organics washed with water
3. dry with materialdried (MgSO4)
4. customevaporated under reduced pressure
5. customThe residue was purified by chromatography on silica eluting with 2:1 ethyl acetate in isohexane