反应详情

Sodium hydride (0.44 g, 60% dispersion in oil) was added portionwise to a stirred solution of 4-chloro-2-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine (2 g) in N,N-dimethylformamide (30 ml) at 0° C. After 0.75 h, ethyl iodide (0.88 ml) was added, the mixture stirred for 2 h, quenched with water and partitioned between ethyl acetate and brine. The organics were washed with water, dried (MgSO4), evaporated under reduced pressure and the residue purified by chromatography on silica eluting with 15% ethyl acetate in isohexane. Yield 1.98 g

1. customquenched with water
2. custompartitioned between ethyl acetate and brine
3. washThe organics were washed with water
4. dry with materialdried (MgSO4)
5. customevaporated under reduced pressure
6. customthe residue purified by chromatography on silica eluting with 15% ethyl acetate in isohexane