反应详情

温度

90 °C

3.0 g of 1-chloro-isoquinoline (18 mmmol), 2.7 g of phenylboronic acid (21 mmol), 1.6 g of tetrakis-triphenyl phosphine palladium (0.8 mmol %), and 2.9 g of potassium carbonate (21 mmol) were added into 100 ml of reaction bowl, and 50 ml of ethylene glycol-dimethyl ether as distilled solvent was added thereto under the flow of nitrogen, and then the reaction was performed in reflux at 90° C. for 12 hr. The mixture was cooled to room temperature, extracted by chloroform and distilled water, and then, separated by silica gel column chromatography (chloroform:hexane=1:3), to obtain 3.32 g of 1-phenyl-isoquinoline (yield: 90%).

1. distillationas distilled solvent
2. additionwas added
3. temperatureThe mixture was cooled to room temperature
4. extractionextracted by chloroform
5. distillationdistilled water
6. customseparated by silica gel column chromatography (chloroform:hexane=1:3)