Benzyl Bromide → HCID 86608238, compound

HRID 2117261Notes

Reaction equation

HRID 2117261 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1([C:18]([OH:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[Cs+].[Cs+].[CH2:27](Br)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>CN(C)C=O>[C:1]([O:5][C:6]([NH:8][C:9]1([C:18]([O:20][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 10796Cesium carbonateHCID 27331951-[(tert-Butoxycarbonyl)amino]-2,3-dihydro-1H-indene-1-carboxylic acid

Product 1

HCID 86608238HCID 86608238, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

To 0.140 mol of 1-[(tert-butyloxycarbonyl)amino]-1-indancarboxylic acid there are added 750 ml of dimethylformamide and then 0.147 mol of caesium carbonate. Stirring is then carried out for 2 hours 30 minutes at ambient temperature and there is then poured in, dropwise, over ½ hour, 0.145 mol of benzyl bromide dissolved in 150 ml of dimethyl-formamide, and stirring is carried out for 20 hours at ambient temperature.

Workup

  1. additionthere is then poured in, dropwise, over ½ hour
  2. stirringstirring
  3. waitis carried out for 20 hours at ambient temperature

Sources & evidence

ORD record
ord-18beb380a27e4a92bb0c8a78ee6d4925
Source dataset
uspto-grants-2008_10
Patent number
US07442692B2

Reaction notes

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