反应详情

温度

110 °C

To a stirred solution of 1-benzofuran-6-ol (309 mg, 2.3 mmol) in dioxane (6 mL) and DMF (12 mL) was added 2-methyl-4-trifluoromethylphenyl iodide (600 mg, 2.3 mmol), copper iodide (108 mg, 0.57 mmol), dimethylglycine hydrochloride (243 mg, 1.7 mmol), and cesium carbonate (1.88 g, 5.8 mmol). The reaction was stirred at 110° C. for 22 h. After cooling to room temperature, solvents were removed in vacuo. The residue was dissolved in ethyl acetate, washed with water and brine, dried and concentrated. The crude product was purified on a silica gel column, eluting with ethyl acetate (0-10%) in hexanes. The final product was collected as a slightly yellow oil.

1. temperatureAfter cooling to room temperature
2. customsolvents were removed in vacuo
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with water and brine
5. customdried
6. concentrationconcentrated
7. customThe crude product was purified on a silica gel column
8. washeluting with ethyl acetate (0-10%) in hexanes
9. customThe final product was collected as a slightly yellow oil