Sodium Iodide → HCID 13934594, compound

HRID 2118731Notes

Reaction equation

HRID 2118731 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][N:17]=3)[C:12](=[O:19])[C:11]3[CH2:20][CH2:21][O:22][C:10]2=3)=[CH:5][CH:4]=1.[I-].[Na+]>CC(N(C)C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:18]3[N:17]=[CH:16][CH:15]=[CH:14][C:13]=3[C:12]3[O:19][CH2:21][CH2:20][C:11]=3[C:10]2=[O:22])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 13934613HCID 13934613, compound

Product 1

HCID 13934594HCID 13934594, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

A solution of 3,9-dihydro-9-(4-methoxyphenyl)-furo[2,3-b][1,8]naphthyridin-4(2H)-one (1 g.) and sodium iodide (1 g.) in dry dimethylacetamide (10 ml.) was heated to 70° C. for 4 hr in a nitrogen atmosphere. The product was cooled, poured over ice-water, filtered, dried and recrystallized from CH2Cl2 to yield the desired product, m.p. 282°-284° C.

Workup

  1. temperatureThe product was cooled
  2. filtrationfiltered
  3. customdried
  4. customrecrystallized from CH2Cl2

Sources & evidence

ORD record
ord-f50cf2c4fb094badaad433026f86ab40
Source dataset
uspto-grants-1987_07
Patent number
US04680298

Reaction notes

Loading…