Hydrochloric Acid → HCID 53841168, compound

HRID 2118959Notes

Reaction equation

HRID 2118959 reaction equation
[NH2:1][S:2]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[Cl:15])[NH:11][CH:10]([C:16]1[CH:17]=[C:18]([CH:40]=[CH:41][CH:42]=1)[O:19][C@@H:20]1[CH2:24][N:23]([C:25]([N:27]([CH2:30][CH2:31][C:32]([O:34]CC)=[O:33])[CH2:28][CH3:29])=[O:26])[C@H:22]([C:37]([OH:39])=[O:38])[CH2:21]1)[NH:9][C:8]2=[O:43])(=[O:4])=[O:3].[OH-].[Na+].Cl>O1CCCC1>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[Cl:15])[NH:11][CH:10]([C:16]1[CH:17]=[C:18]([CH:40]=[CH:41][CH:42]=1)[O:19][C@@H:20]1[CH2:24][N:23]([C:25]([N:27]([CH2:30][CH2:31][C:32]([OH:34])=[O:33])[CH2:28][CH3:29])=[O:26])[C@H:22]([C:37]([OH:39])=[O:38])[CH2:21]1)[NH:9][C:8]2=[O:43])(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53665640HCID 53665640, compound

Product 1

HCID 53841168HCID 53841168, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product from Example 11 is dissolved in aqueous tetrahydrofuran and treated with a molar excess of aqueous sodium hydroxide. After the reaction is complete, the solution is acidified with dilute hydrochloric acid to precipitate out (cis)-4-[3-[6-(aminosulfonyl)-7-chloro-1,2,3,4-tetrahysro-4-oxo-2-quinazolinyl]phenoxy]-1-[[(2-carboxyethyl)ethylamino]carbonyl]-L-proline.

Workup

  1. customto precipitate out (cis)-4-[3-[6-(aminosulfonyl)-7-chloro-1,2,3,4-tetrahysro-4-oxo-2-quinazolinyl]phenoxy]-1-[[(2-carboxyethyl)ethylamino]carbonyl]-L-proline

Sources & evidence

ORD record
ord-60f30d0b06074140bd583eafad1b01e0
Source dataset
uspto-grants-1987_07
Patent number
US04681886

Reaction notes

Loading…