Chlorosuccinimide → HCID 13923651, compound

HRID 2119021Notes

Reaction equation

HRID 2119021 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH:10]([CH:12]3[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]3)[C:9]3=[CH:19][CH:20]=[CH:21][N:8]3[CH2:7][C:6]=2[CH:22]=1.[Cl:23]N1C(=O)CCC1=O>O1CCCC1>[Cl:23][C:21]1[N:8]2[C:9]([CH:10]([CH:12]3[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]3)[O:11][C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:22][C:6]=3[CH2:7]2)=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 13851471HCID 13851471, compound

Product 1

HCID 13923651HCID 13923651, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 7-chloro-11-[(1-methyl)piperidin-4-yl]5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (4.0 g; 0.013 mole) and N-chlorosuccinimide (2.0 g; 0.015) mole in 150 ml of tetrahydrofuran was heated at reflux for 4.5 hours.

Workup

  1. temperatureat reflux for 4.5 hours

Sources & evidence

ORD record
ord-6c88ac11013f41e7bcb62ec04007a99d
Source dataset
uspto-grants-1987_07
Patent number
US04681879

Reaction notes

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