Potassium Carbonate → 1-(5-Bromopyridin-2-yl)piperidin-4-ol

HRID 2120112Notes

Reaction equation

HRID 2120112 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[OH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.C(=O)([O-])[O-].[K+].[K+]>CN1CCCC1=O>[OH:9][CH:10]1[CH2:15][CH2:14][N:13]([C:2]2[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=2)[CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 693532,5-DibromopyridineHCID 79341Piperidin-4-ol

Product 1

HCID 218978371-(5-Bromopyridin-2-yl)piperidin-4-ol

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

In 100 ml of 1-methyl-2-pyrrolidone was dissolved 10 g of 2,5-dibromopyridine which was then added with 5.2 g of 4-hydroxypiperidine, along with 17.5 g of potassium carbonate at room temperature. Reaction was conducted at 100° C. for 3 hours with stirring. After completion of the reaction, the same post-treatment as in Preparation Example 13 was carried out to obtain the title compound. 9 g.

Workup

  1. customReaction
  2. customAfter completion of the reaction
  3. customthe same post-treatment as in Preparation Example 13

Sources & evidence

ORD record
ord-c051cf8ad3084888b4dd6064c398882e
Source dataset
uspto-grants-2004_02
Patent number
US06689779B2

Reaction notes

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