Lithium Hydroxide → HCID 23439302, compound

HRID 2120406Notes

Reaction equation

HRID 2120406 reaction equation
[F:1][C:2]([CH3:33])([CH3:32])[CH2:3][CH2:4][CH:5]1[C:9](=[O:10])[O:8][CH:7]([CH:11]([NH:19][C:20]([C:22]2[CH:31]=[N:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:23]=2)=[O:21])[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:6]1.[OH-:34].[Li+]>O1CCCC1>[F:1][C:2]([CH3:32])([CH3:33])[CH2:3][CH2:4][CH:5]([CH2:6][CH:7]([OH:34])[CH:11]([NH:19][C:20]([C:22]1[CH:31]=[N:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:23]=1)=[O:21])[CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:9]([OH:8])=[O:10]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 76502387HCID 76502387, compound

Product 1

HCID 23439302HCID 23439302, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of quinoxaline-2-carboxylic acid {1-[4-(3-fluoro-3-methyl-butyl)-5-oxo-tetrahydro-furan-2-yl]-2-phenyl-ethyl}-amide (4 g, 8.90 mmol) in tetrahydrofuran was added lithium hydroxide (1 M in water, 28 mL) and stirred for 2 hours. The reaction was then concentrated, and concentrated from benzene (2×) to give the title compound (4.2 g, 100%).

Workup

  1. concentrationThe reaction was then concentrated
  2. concentrationconcentrated from benzene (2×)

Sources & evidence

ORD record
ord-df94906a655a4e4abbf864ae6ca1eee8
Source dataset
uspto-grants-2004_02
Patent number
US06689886B2

Reaction notes

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