Dimethylformamide → 6-Chloro-N-methoxy-N-methylnicotinamide

Temperature

40 °C

To a solution of 6-chloronicotine carboxylic acid (40 g, 284 mmol) in dichloromethane (500 mL) was added 5 mL of N,N-dimethylformamide (DMF). At ambient temperature, a 2 M solution of oxalyl chloride in dichloromethane (167 mL, 330 mmol) was added dropwise. The reaction mixture was heated to 40° C. for two hours and then stirred at room temperature for 18 hours. The acid chloride solution was concentrated in vacuo, and placed under vacuum for one hour. To a solution of N,O-dimethylhydroxylamine hydrochloride (32 g, 330 mmol) in dichloromethane (400 mL) was added triethylamine (70 mL); the mixture was then cooled to 0° C. A solution of the previously formed acid chloride in dichloromethane (100 mL) was added dropwise at a rate keeping the temperature at 0° C. After the addition, the ice bath was removed and the reaction mixture was allowed to warm to room temperature and stirred for 20 hours. The reaction mixture was then layered with saturated sodium hydrogenphosphate and the organic layer was extracted, washed with water, brine, dried with sodium sulfate and filtered. The solution was concentrated in vacuo yielding the title compound (48.9 g, 96%).

1. concentrationThe acid chloride solution was concentrated in vacuo
2. waitplaced under vacuum for one hour
3. temperaturethe mixture was then cooled to 0° C
4. customat 0° C
5. additionAfter the addition
6. customthe ice bath was removed
7. temperatureto warm to room temperature
8. stirringstirred for 20 hours
9. extractionthe organic layer was extracted
10. washwashed with water, brine
11. dry with materialdried with sodium sulfate
12. filtrationfiltered
13. concentrationThe solution was concentrated in vacuo

ORD record

ord-896421db35ea446680f412a13cf7556f

Source dataset

uspto-grants-2004_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06696464B2