反应详情

温度

0 °C

To a stirred cold (0° C.) solution of 5.5 g of 5-bromo-pyridin-2-yl-hydrazine in 40 mL of dichloromethane, 30 mL of N,N-dimethylformamide, and 26 mL of N,N-diisopropylethylamine was added 3.1 ml of isobutyryl chloride dropwise. The mixture was stirred at 0° C. for 1 hour and a precipitate formed. The mixture was diluted with water and the solids were collected by filtration to give 5.9 g of isobutyric acid N′-(5-bromo-pyridin-2-yl)-hydrazide as a light yellow solid.

1. customa precipitate formed
2. filtrationthe solids were collected by filtration