1-Butanol → 1-[3-[(4-Cyclohexylquinazolin-2-yl)amino]pyrrolidin-1-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone
Reaction equation
[CH2:53]([OH:54])[CH2:55][CH2:56][CH3:57].[CH3:58][N:59]1[CH2:60][CH2:61][CH2:62][C:63]1=[O:64].[CH:39]([N:40]([CH2:41][CH3:42])[CH:43]([CH3:44])[CH3:45])([CH3:46])[CH3:47].[Cl:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[c:10]([CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)[n:11]1.[ClH:18].[NH2:19][CH:20]1[CH2:21][N:22]([C:25]([CH2:26][c:27]2[cH:28][cH:29][c:30]([O:33][C:34]([F:35])([F:36])[F:37])[cH:31][cH:32]2)=[O:38])[CH2:23][CH2:24]1.[Na+:48].[OH:49][C:50](=[O:51])[O-:52]>>[c:2]1([NH:19][CH:20]2[CH2:21][N:22]([C:25]([CH2:26][c:27]3[cH:28][cH:29][c:30]([O:33][C:34]([F:35])([F:36])[F:37])[cH:31][cH:32]3)=[O:38])[CH2:23][CH2:24]2)[n:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[c:10]([CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)[n:11]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-c6dcc0c6dfe541858564063aed76e8b8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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