Hydrochloric Acid → 4-[8-Chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

HRID 2124702Notes

Reaction equation

HRID 2124702 reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[Cl:1][c:2]1[c:3]([O:37][CH3:38])[cH:4][cH:5][c:6]2[c:7]([O:20][CH:21]3[CH2:22][CH:23]([C:33](=[O:34])[O:35][CH3:36])[N:24]([C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:25]3)[cH:8][c:9](-[c:12]3[s:13][cH:14][c:15]([CH:17]([CH3:18])[CH3:19])[n:16]3)[n:10][c:11]12.[ClH:42].[Li+:40].[OH-:41].[OH2:39]>>[Cl:1][c:2]1[c:3]([O:37][CH3:38])[cH:4][cH:5][c:6]2[c:7]([O:20][CH:21]3[CH2:22][CH:23]([C:33](=[O:34])[OH:35])[N:24]([C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:25]3)[cH:8][c:9](-[c:12]3[s:13][cH:14][c:15]([CH:17]([CH3:18])[CH3:19])[n:16]3)[n:10][c:11]12

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 961HydroxideHCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 666504001-O-tert-butyl 2-O-methyl 4-[8-chloro-7-methoxy-2-(4-propan-2-yl-1,3-thiazol-2-yl)quinolin-4-yl]oxypyrrolidine-1,2-dicarboxylate

Product 1

HCID 673193434-[8-Chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Sources & evidence

ORD record
ord-fa44bdf5c1f74e0c9e6f3387318e84db
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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