Dimethylformamide → Methyl 4-cyano-6-[[3-methoxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]amino]-2-(3-methylanilino)pyridine-3-carboxylate

HRID 2125065Notes

Reaction equation

HRID 2125065 reaction equation
[CH3:50][CH2:51][O:52][C:53]([CH3:54])=[O:55].[CH:36]([N:37]([CH2:38][CH3:39])[CH:40]([CH3:41])[CH3:42])([CH3:43])[CH3:44].[Cl:1][c:2]1[n:3][c:4]([NH:14][c:15]2[cH:16][c:17]([CH3:21])[cH:18][cH:19][cH:20]2)[c:5]([C:6](=[O:7])[O:8][CH3:9])[c:10]([C:12]#[N:13])[cH:11]1.[NH2:22][CH2:23][CH:24]([CH2:25][O:26][CH3:27])[NH:28][C:29]([O:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:35].[O:45]=[CH:46][N:47]([CH3:48])[CH3:49]>>[c:2]1([NH:22][CH2:23][CH:24]([CH2:25][O:26][CH3:27])[NH:28][C:29]([O:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:35])[n:3][c:4]([NH:14][c:15]2[cH:16][c:17]([CH3:21])[cH:18][cH:19][cH:20]2)[c:5]([C:6](=[O:7])[O:8][CH3:9])[c:10]([C:12]#[N:13])[cH:11]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 45092031tert-butyl N-(1-amino-3-methoxypropan-2-yl)carbamateHCID 58317587Methyl 6-chloro-4-cyano-2-(m-tolylamino)nicotinate

Product 1

HCID 67238995Methyl 4-cyano-6-[[3-methoxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]amino]-2-(3-methylanilino)pyridine-3-carboxylate

Sources & evidence

ORD record
ord-f550919470b240eba81016aee136bba7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…