Hydrogen Bromide → 5-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine

HRID 2127778Notes

Reaction equation

HRID 2127778 reaction equation
[Br:23][CH2:24][c:25]1[c:26]([NH2:32])[n:27][c:28]([NH2:31])[n:29][cH:30]1.[BrH:21].[BrH:22].[CH3:14][CH2:15][N:16]([CH2:17][CH3:18])[CH2:19][CH3:20].[CH3:33][N:34]([CH3:35])[CH:36]=[O:37].[c:1]1([CH3:13])[cH:2][cH:3][c:4]([N:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[cH:5][cH:6]1>>[c:1]1([CH3:13])[cH:2][cH:3][c:4]([N:7]2[CH2:8][CH2:9][N:10]([CH2:24][c:25]3[c:26]([NH2:32])[n:27][c:28]([NH2:31])[n:29][cH:30]3)[CH2:11][CH2:12]2)[cH:5][cH:6]1

Participants

6

Reactant 5

HCID 260Hydrogen Bromide2×HCID 6228DimethylformamideHCID 8471TriethylamineHCID 831131-(p-Tolyl)piperazineHCID 4273182,4-Diamino-5-(bromomethyl)pyrimidine

Product 1

HCID 214736335-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine

Sources & evidence

ORD record
ord-a4dd37fd2d8f404d8704990d08b23544
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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