Hydrochloric Acid → 1'-(4-Methoxy-3-(trifluoromethyl)benzoyl)spiro[chroman-2,4'-piperidin]-4-one
Reaction equation
[CH2:11]1[CH2:12][NH:13][CH2:14][CH2:15]1.[CH3:16][O:17][c:18]1[c:19]([C:33]([F:34])([F:35])[F:36])[cH:20][c:21]([C:22](=[O:23])[N:24]2[CH2:25][CH2:26][C:27](=[O:30])[CH2:28][CH2:29]2)[cH:31][cH:32]1.[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46].[CH3:47][OH:48].[Cl:38][CH2:39][Cl:40].[ClH:37].[OH:1][c:2]1[c:3]([C:8]([CH3:9])=[O:10])[cH:4][cH:5][cH:6][cH:7]1>>[O:1]1[c:2]2[c:3]([cH:4][cH:5][cH:6][cH:7]2)[C:8](=[O:10])[CH2:9][C:27]12[CH2:26][CH2:25][N:24]([C:22]([c:21]1[cH:20][c:19]([C:33]([F:34])([F:35])[F:36])[c:18]([O:17][CH3:16])[cH:32][cH:31]1)=[O:23])[CH2:29][CH2:28]2Participants
8
Sources & evidence
- ORD record
- ord-465aaafbe2e24e7d9380072b205bd811
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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