Tetrahydrofuran → 2-Fluoro-5-(trifluoromethoxy)benzonitrile

HRID 2129140Notes

Reaction equation

[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:16][CH2:17][N:18]([CH2:19][CH3:20])[CH2:21][CH3:22].[F:1][c:2]1[c:3]([CH:4]=[N:5][OH:6])[cH:7][c:8]([O:11][C:12]([F:13])([F:14])[F:15])[cH:9][cH:10]1.[F:23][C:24]([F:25])([F:26])[C:27]([O:28][C:29](=[O:30])[C:31]([F:32])([F:33])[F:34])=[O:35]>>[F:1][c:2]1[c:3]([C:4]#[N:5])[cH:7][c:8]([O:11][C:12]([F:13])([F:14])[F:15])[cH:9][cH:10]1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 9845Trifluoroacetic anhydride

HCID 173080642N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methylidene]hydroxylamine

Product 1

HCID 52210952-Fluoro-5-(trifluoromethoxy)benzonitrile

Sources & evidence

ORD record: ord-04690633c3144020bd27f7d2e86562bf
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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