Hydrochloric Acid → Lesinurad

HRID 212933Notes

Reaction equation

HRID 212933 reaction equation
[Br:3][c:4]1[n:5](-[c:15]2[cH:16][cH:17][c:18]([CH:25]3[CH2:26][CH2:27]3)[c:19]3[cH:20][cH:21][cH:22][cH:23][c:24]23)[c:6]([S:9][CH2:10][C:11](=[O:12])[O:13][CH3:14])[n:7][n:8]1.[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:30][CH2:31][OH:32].[ClH:28].[Li+:1].[OH-:2].[OH2:29]>>[Br:3][c:4]1[n:5](-[c:15]2[cH:16][cH:17][c:18]([CH:25]3[CH2:26][CH2:27]3)[c:19]3[cH:20][cH:21][cH:22][cH:23][c:24]23)[c:6]([S:9][CH2:10][C:11](=[O:12])[OH:13])[n:7][n:8]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 702EthanolHCID 961HydroxideHCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 57811446Methyl 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate

Product 1

HCID 53465279Lesinurad

Sources & evidence

ORD record
ord-b8860ab10037401c801f2980c4233b9d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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