Acetate → 3-(Isoquinolin-4-yl)acrylic Acid t-Butyl Ester

HRID 2129421Notes

Reaction equation

HRID 2129421 reaction equation
[Br:1][c:2]1[cH:3][n:4][cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12.[C:12]([CH3:13])([CH3:14])([CH3:15])[O:16][C:17]([CH:18]=[CH2:19])=[O:20].[CH:21]([N:22]([CH2:23][CH3:24])[CH:25]([CH3:26])[CH3:27])([CH3:28])[CH3:29].[O-:36][C:37]([CH3:38])=[O:39].[O-:40][C:41]([CH3:42])=[O:43].[O:30]=[CH:31][N:32]([CH3:33])[CH3:34].[Pd+2:35]>>[c:2]1([CH:19]=[CH:18][C:17]([O:16][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:20])[cH:3][n:4][cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12

Participants

7

Reactant 6

HCID 175Acetate2×HCID 6228DimethylformamideHCID 15458tert-Butyl acrylateHCID 737434-BromoisoquinolineHCID 81531DiisopropylethylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

Product 1

HCID 684144603-(Isoquinolin-4-yl)acrylic Acid t-Butyl Ester

Sources & evidence

ORD record
ord-142bc2b28fe548c9ae4093e547fc9e9a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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