Dichloromethane → 5-chloro-N-(6-methoxypyridin-3-yl)-3-(2-methyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-amine
Reaction equation
[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[CH3:10][Si:11]([N-:12][Si:13]([CH3:14])([CH3:15])[CH3:16])([CH3:17])[CH3:18].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([NH2:9])[cH:7][n:8]1.[Cl:20][c:21]1[cH:22][c:23](-[c:28]2[c:29]3[n:30][cH:31][n:32]([CH:38]4[O:39][CH2:40][CH2:41][CH2:42][CH2:43]4)[c:33]3[n:34][c:35]([CH3:37])[n:36]2)[c:24]([F:27])[n:25][cH:26]1.[Cl:49][CH2:50][Cl:51].[Li+:19]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([NH:9][c:24]2[c:23](-[c:28]3[c:29]4[n:30][cH:31][n:32]([CH:38]5[O:39][CH2:40][CH2:41][CH2:42][CH2:43]5)[c:33]4[n:34][c:35]([CH3:37])[n:36]3)[cH:22][c:21]([Cl:20])[cH:26][n:25]2)[cH:7][n:8]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-2950c92f9ab14dda99d4285de54c94ae
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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