反应详情

To a dry 250 ml flask equipped with a magnetic stirrer, Dean-Stark trap, and reflux condenser was charged 15 g of 4-chlorobenzaldehyde, 12.4 g levulenic acid, 5.7 ml of piperidine, and 100 ml of toluene. The reaction was refluxed for 3 hours, after which no water was observed to azeotrope from the solution. The reaction was cooled and stripped to yield a reddish-brown liquid which was triturated with hexane to yield 11.2 g of product as a yellow solid.

1. customTo a dry 250 ml flask equipped with a magnetic stirrer
2. temperatureDean-Stark trap, and reflux condenser
3. temperatureThe reaction was refluxed for 3 hours
4. temperatureThe reaction was cooled
5. customto yield a reddish-brown liquid which
6. customwas triturated with hexane