Cyanide → 8-Cyano-10-(2-cyclopropylethyl)-10-(trifluoromethyl)-5,10-dihydropyrimido[5,4-b]quinolin-4(3H)-one
Reaction equation
[C-:33]#[N:34].[C-:36]#[N:37].[CH3:26][N:27]1[CH2:28][CH2:29][CH2:30][C:31]1=[O:32].[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][c:7]1[c:6]([n:15][cH:14][nH:13][c:12]1=[O:16])[C:5]2([C:17]([F:18])([F:19])[F:20])[CH2:21][CH2:22][CH:23]1[CH2:24][CH2:25]1.[Zn+2:35]>>[c:2]1([C:26]#[N:27])[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][c:7]1[c:6]([n:15][cH:14][nH:13][c:12]1=[O:16])[C:5]2([C:17]([F:18])([F:19])[F:20])[CH2:21][CH2:22][CH:23]1[CH2:24][CH2:25]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-526c7a4f8dcb4b7d9e23e13fbcdceef3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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