Tetrahydrofuran → 2-(4-(4-methyl-5-(pyridin-3-ylmethylcarbamoyl)thiazol-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)ethyl methanesulfonate

HRID 2131643Notes

Reaction equation

HRID 2131643 reaction equation
[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[CH3:33][S:34]([Cl:35])(=[O:36])=[O:37].[CH3:43][CH2:44][O:45][C:46](=[O:47])[CH3:48].[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1.[OH:1][CH2:2][CH2:3][n:4]1[n:5][cH:6][n:7](-[c:10]2[s:11][c:12]([C:16](=[O:17])[NH:18][CH2:19][c:20]3[cH:21][n:22][cH:23][cH:24][cH:25]3)[c:13]([CH3:15])[n:14]2)[c:8]1=[O:9]>>[O:1]([CH2:2][CH2:3][n:4]1[n:5][cH:6][n:7](-[c:10]2[s:11][c:12]([C:16](=[O:17])[NH:18][CH2:19][c:20]3[cH:21][n:22][cH:23][cH:24][cH:25]3)[c:13]([CH3:15])[n:14]2)[c:8]1=[O:9])[S:34]([CH3:33])(=[O:36])=[O:37]

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 31297Methanesulfonyl chlorideHCID 250966952-(1-(2-hydroxyethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide

Product 1

HCID 594812642-(4-(4-methyl-5-(pyridin-3-ylmethylcarbamoyl)thiazol-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)ethyl methanesulfonate

Sources & evidence

ORD record
ord-03e4e5acf631450db39579f2fa0ee812
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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