Ammonia → 5-([1,1'-Biphenyl]-4-ylmethyl)pyrrolidin-2-one

HRID 2141027Notes

Reaction equation

HRID 2141027 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][cH:10][cH:11][cH:12][cH:13]2)[cH:6][cH:7]1.[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[CH2:54]1[O:55][CH2:56][CH2:57][O:58][CH2:59]1.[Cl-:47].[Cu:14][C:15]#[N:16].[NH3:46].[NH4+:48].[O-:35][S:36]([c:37]1[cH:38][cH:39][c:40]([CH3:41])[cH:42][cH:43]1)(=[O:44])=[O:45].[O:17]=[C:18]1[CH2:19][CH2:20][CH:21]([CH2:23][O:24][S:25]([c:26]2[cH:27][cH:28][c:29]([CH3:30])[cH:31][cH:32]2)(=[O:33])=[O:34])[NH:22]1>>[c:2]1([CH2:23][CH:21]2[CH2:20][CH2:19][C:18](=[O:17])[NH:22]2)[cH:3][cH:4][c:5](-[c:8]2[cH:9][cH:10][cH:11][cH:12][cH:13]2)[cH:6][cH:7]1

Participants

10

Reactant 9

HCID 222AmmoniaHCID 223AmmoniumHCID 312ChlorideHCID 71014-BromobiphenylHCID 8028TetrahydrofuranHCID 312751,4-DioxaneHCID 85570p-ToluenesulfonateHCID 28146098243-59-5HCID 178418546HCID 178418546, compound

Product 1

HCID 593184595-([1,1'-Biphenyl]-4-ylmethyl)pyrrolidin-2-one

Sources & evidence

ORD record
ord-3aeeecb6fd254676acb9f3916ada8889
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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