Tetrahydrofuran → N-[6-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl]-4-(2-oxo-4-phenylimidazolidin-1-yl)piperidine-1-carboxamide

HRID 2142298Notes

Reaction equation

HRID 2142298 reaction equation
[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[Cl:29][C:30](=[O:31])[O:32][c:33]1[cH:34][cH:35][c:36]([N+:37]([O-:38])=[O:39])[cH:40][cH:41]1.[NH2:8][CH:9]1[C:10](=[O:28])[N:11]([CH2:24][CH2:25][O:26][CH3:27])[CH2:12][CH:13]([c:16]2[c:17]([F:23])[c:18]([F:22])[cH:19][cH:20][cH:21]2)[CH2:14][CH2:15]1.[O:60]1[CH2:61][CH2:62][CH2:63][CH2:64]1.[c:42]1([CH:48]2[NH:49][C:50](=[O:59])[N:51]([CH:53]3[CH2:54][CH2:55][NH:56][CH2:57][CH2:58]3)[CH2:52]2)[cH:43][cH:44][cH:45][cH:46][cH:47]1>>[NH:8]([CH:9]1[C:10](=[O:28])[N:11]([CH2:24][CH2:25][O:26][CH3:27])[CH2:12][CH:13]([c:16]2[c:17]([F:23])[c:18]([F:22])[cH:19][cH:20][cH:21]2)[CH2:14][CH2:15]1)[C:30](=[O:31])[N:56]1[CH2:55][CH2:54][CH:53]([N:51]2[C:50](=[O:59])[NH:49][CH:48]([c:42]3[cH:43][cH:44][cH:45][cH:46][cH:47]3)[CH2:52]2)[CH2:58][CH2:57]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 821294-Nitrophenyl chloroformateHCID 222932393-Amino-6-(2,3-difluorophenyl)-1-(2-methoxyethyl)azepan-2-oneHCID 575625114-Phenyl-1-piperidin-4-yl-imidazolidin-2-one

Product 1

HCID 72788329N-[6-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl]-4-(2-oxo-4-phenylimidazolidin-1-yl)piperidine-1-carboxamide

Sources & evidence

ORD record
ord-e6bfbb25e7984d51beab96f610942e49
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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