Dimethylformamide → 7-chloro-3-(piperidin-4-yl)-1H-indole

HRID 2142500Notes

Reaction equation

HRID 2142500 reaction equation
[CH3:33][N:34]([CH3:35])[c:36]1[cH:37][cH:38][n:39][cH:40][cH:41]1.[CH:24]([N:25]([CH:26]([CH3:27])[CH3:28])[CH2:29][CH3:30])([CH3:31])[CH3:32].[Cl:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]([CH:11]3[CH2:12][CH2:13][N:14]([C:17]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:23])[CH2:15][CH2:16]3)[cH:8][nH:9][c:10]12.[O:42]=[CH:43][N:44]([CH3:45])[CH3:46]>>[Cl:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]([CH:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)[cH:8][nH:9][c:10]12

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 142844-(Dimethylamino)pyridineHCID 81531DiisopropylethylamineHCID 120720357-chloro-3-(1-tert-butoxycarbonylpiperidin-4-yl)-1H-indole

Product 1

HCID 120720367-chloro-3-(piperidin-4-yl)-1H-indole

Sources & evidence

ORD record
ord-8a41f95361f44ecfbb34b6d8d87bfabf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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