Dimethylformamide → 3-bromo-5-(trifluoromethyl)-N-(3-(1,2-dihydro-1,7-dimethyl-2-oxo-1,6-naphthyridin-3-yl)-4-methylphenyl)benzamide

HRID 214407Notes

Reaction equation

HRID 214407 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[OH:7])[cH:8][c:9]([C:11]([F:12])([F:13])[F:14])[cH:10]1.[CH3:74][CH2:75][O:76][C:77]([CH3:78])=[O:79].[CH:39]([N:40]([CH:41]([CH3:42])[CH3:43])[CH2:44][CH3:45])([CH3:46])[CH3:47].[NH2:48][c:49]1[cH:50][cH:51][c:52]([CH3:68])[c:53](-[c:55]2[c:56](=[O:67])[n:57]([CH3:66])[c:58]3[cH:59][c:60]([CH3:65])[n:61][cH:62][c:63]3[cH:64]2)[cH:54]1.[O:69]=[CH:70][N:71]([CH3:72])[CH3:73].[P-:15]([F:16])([F:17])([F:18])([F:19])([F:20])[F:21].[n:22]1([O:23][C:24]([N:25]([CH3:26])[CH3:27])=[N+:28]([CH3:29])[CH3:30])[c:31]2[n:32][cH:33][cH:34][cH:35][c:36]2[n:37][n:38]1>>[Br:1][c:2]1[cH:3][c:4]([C:5](=[O:7])[NH:48][c:49]2[cH:50][cH:51][c:52]([CH3:68])[c:53](-[c:55]3[c:56](=[O:67])[n:57]([CH3:66])[c:58]4[cH:59][c:60]([CH3:65])[n:61][cH:62][c:63]4[cH:64]3)[cH:54]2)[cH:8][c:9]([C:11]([F:12])([F:13])[F:14])[cH:10]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 110867883-Bromo-5-(trifluoromethyl)benzoic acidHCID 592123103-(5-amino-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one

Product 1

HCID 592125063-bromo-5-(trifluoromethyl)-N-(3-(1,2-dihydro-1,7-dimethyl-2-oxo-1,6-naphthyridin-3-yl)-4-methylphenyl)benzamide

Sources & evidence

ORD record
ord-dd19072eba1b42aa853d71a93449c742
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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