Chloride → ethyl (2RS,3RS)-3-(4-((4-chloro-3-ethylphenyl)oxy)phenyl)-3-hydroxy-2-((3-((1,1,2,2-tetrafluoroethyl)oxy)phenyl)methyl)propionate

HRID 2147201Notes

Reaction equation

HRID 2147201 reaction equation
[BH4-:1].[CH3:43][CH2:44][O:45][CH2:46][CH3:47].[Cl-:48].[Cl-:50].[Cl:3][c:4]1[c:5]([CH2:39][CH3:40])[cH:6][c:7]([O:10][c:11]2[cH:12][cH:13][c:14]([C:17]([CH:18]([C:19](=[O:20])[O:21][CH2:22][CH3:23])[CH2:24][c:25]3[cH:26][c:27]([O:31][C:32]([CH:33]([F:34])[F:35])([F:36])[F:37])[cH:28][cH:29][cH:30]3)=[O:38])[cH:15][cH:16]2)[cH:8][cH:9]1.[ClH:41].[Na+:2].[OH2:42].[Zn+2:49]>>[Cl:3][c:4]1[c:5]([CH2:39][CH3:40])[cH:6][c:7]([O:10][c:11]2[cH:12][cH:13][c:14]([CH:17]([CH:18]([C:19](=[O:20])[O:21][CH2:22][CH3:23])[CH2:24][c:25]3[cH:26][c:27]([O:31][C:32]([CH:33]([F:34])[F:35])([F:36])[F:37])[cH:28][cH:29][cH:30]3)[OH:38])[cH:15][cH:16]2)[cH:8][cH:9]1

Participants

9

Reactant 8

HCID 312Chloride2×HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 962WaterHCID 3283Diethyl EtherHCID 28123BorohydrideHCID 32051Zinc(2+)HCID 22261529HCID 22261529, compound

Product 1

HCID 22262350ethyl (2RS,3RS)-3-(4-((4-chloro-3-ethylphenyl)oxy)phenyl)-3-hydroxy-2-((3-((1,1,2,2-tetrafluoroethyl)oxy)phenyl)methyl)propionate

Sources & evidence

ORD record
ord-175c8579a97a42bcb48aa13a2fff48ca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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