Pyridine → 4-[(3-Bromophenyl)amino]-7-[3-(1-methylpiperidin-4-yl)propyloxy]-6-[(1-oxo-2,4-hexadien-1-yl)amino]quinazoline
Reaction equation
[C:1]([CH:2]=[CH:3][CH:4]=[CH:5][CH3:6])(=[O:7])[OH:8].[CH3:17][N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1.[Cl:9][C:10]([O:11][CH2:12][CH:13]([CH3:14])[CH3:15])=[O:16].[NH2:24][c:25]1[cH:26][c:27]2[c:28]([NH:46][c:47]3[cH:48][c:49]([Br:53])[cH:50][cH:51][cH:52]3)[n:29][cH:30][n:31][c:32]2[cH:33][c:34]1[O:35][CH2:36][CH2:37][CH2:38][CH:39]1[CH2:40][CH2:41][N:42]([CH3:45])[CH2:43][CH2:44]1.[O:54]1[CH2:55][CH2:56][CH2:57][CH2:58]1.[cH:59]1[cH:60][cH:61][n:62][cH:63][cH:64]1>>[C:1]([CH:2]=[CH:3][CH:4]=[CH:5][CH3:6])(=[O:7])[NH:24][c:25]1[cH:26][c:27]2[c:28]([NH:46][c:47]3[cH:48][c:49]([Br:53])[cH:50][cH:51][cH:52]3)[n:29][cH:30][n:31][c:32]2[cH:33][c:34]1[O:35][CH2:36][CH2:37][CH2:38][CH:39]1[CH2:40][CH2:41][N:42]([CH3:45])[CH2:43][CH2:44]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-23ea3c9dc3634704957dbd12a8df6074
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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